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Hidradenitis suppurativa and metabolic syndrome: a comparative cross‐sectional study of 3207 patients
Author(s) -
Shalom G.,
Freud T.,
HarmanBoehm I.,
Polishchuk I.,
Cohen A.D.
Publication year - 2015
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.13777
Subject(s) - medicine , metabolic syndrome , odds ratio , diabetes mellitus , obesity , hidradenitis suppurativa , cohort , confidence interval , cross sectional study , dyslipidemia , pediatrics , disease , endocrinology , pathology
Summary Background Hidradenitis suppurativa ( HS ) is a chronic relapsing inflammatory skin disease. Objectives To evaluate the association between HS and metabolic syndrome and its component morbidities in a large, community‐based cohort of patients with HS , using the database of C lalit H ealth S ervices, the largest public healthcare provider in I srael. Methods A cross‐sectional study was performed. Metabolic syndrome was defined as the presence of at least three of the following conditions: diabetes, hyperlipidaemia, hypertension and obesity. The association between HS and metabolic syndrome was assessed by a multivariate logistic regression model, adjusting for age, sex, diabetes, hypertension, hyperlipidaemia, obesity and smoking status. Results The study included 3207 patients with HS (general frequency of 0·07%) diagnosed by a dermatologist in primary‐care centres, and 6412 age‐ and sex‐matched control patients without HS . HS was significantly associated with metabolic syndrome [odds ratio ( OR ) 1·61, 95% confidence interval ( CI ) 1·36–1·89], diabetes ( OR 1·41, 95% CI 1·19–1·66), obesity ( OR 1·71, 95% CI 1·53–1·91), hyperlipidaemia ( OR 1·14, 95% CI 1·02–1·28) and hypertension ( OR 1·19, 95% CI 1·03–1·38). Conclusions We found an association between HS and diabetes, hyperlipidaemia, obesity, hypertension and metabolic syndrome among a large community‐based cohort of patients with HS . Clinicians should take into account that patients with HS may have one or more undiagnosed components of metabolic syndrome despite their young age. Thus, appropriate targeted screening is advised.