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Skin reaction and regeneration after single sodium lauryl sulfate exposure stratified by filaggrin genotype and atopic dermatitis phenotype
Author(s) -
Bandier J.,
Carlsen B.C.,
Rasmussen M.A.,
Petersen L.J.,
Johansen J.D.
Publication year - 2015
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.13651
Subject(s) - atopic dermatitis , allergy , medicine , filaggrin , university hospital , dermatology , family medicine , immunology
Summary Background Filaggrin is key for the integrity of the stratum corneum. Mutations in the filaggrin gene ( FLG null) play a prominent role in atopic dermatitis ( AD ) pathogenesis. People with AD have increased susceptibility to irritants. However, little is known about the effect of filaggrin genotype and AD phenotype on irritant response and skin regeneration. Objectives To investigate the role of FLG null and AD groups for skin reaction and recovery after sodium lauryl sulfate ( SLS ) irritation. Methods This is a case–control study comprising 67 subjects, including healthy controls and patients with and without FLG null and AD . Reactivity to different doses of SLS at 24, 48, 72 and 145 h after SLS application was measured by transepidermal water loss ( TEWL ) and laser Doppler flowmetry ( LDF ). Reactivity was assessed univariately and by pattern analysis. Results All patient groups showed a higher degree of skin‐barrier disruption and inflammation than did controls in response to SLS . Assessing reactivity by the delta value of the area under the curve for both TEWL and LDF showed significant differences between healthy controls and those with the AD phenotype, irrespective of filaggrin mutation. The poorest regeneration was among those with the AD phenotype. The two AD phenotype groups were separated by multivariate technique, due to earlier inflammatory reactivity among subjects with FLG null plus AD compared with the AD phenotype alone. Conclusions Both skin reaction and regeneration were significantly different between the patient population and the healthy controls. Additionally, response severity and regeneration depended more on AD phenotype than on filaggrin genotype, whereas the response was more rapid among the FLG null plus AD individuals.