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Distinctive clinical and dermoscopic features of BRAF V600K mutated melanomas
Author(s) -
Ponti G.,
Manfredini M.,
Tomasi A.,
Pellacani G.
Publication year - 2015
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.13484
Subject(s) - neuroblastoma ras viral oncogene homolog , melanoma , medicine , v600e , confidence interval , odds ratio , disease , dermatology , oncology , mutation , cancer , cancer research , genetics , biology , gene , colorectal cancer , kras
dermoscopic criteria associated with BRAF and NRAS mutation status in primary cutaneous melanoma have been recently analyzed by Pozzobon et al. in an interesting study published in your journal. The authors found out that peppering pattern was significantly increased among BRAF mutant melanoma, being present in the 68% of their cases series, with OR 1.68 (CI 95%1.089-2.581, p=0.015).1 The intend of this letter is to underline the dermoscopic features and the distinctive clinical features of BRAF p.V600K melanoma (the second most common BRAF V600 mutation detected in 5 to 30% of cases), that might be slightly different from from BRAF p.V600E melanoma