Premium
Personal history of gallstones and risk of incident psoriasis and psoriatic arthritis in U.S. women
Author(s) -
Tong L.X.,
Wu S.,
Li T.,
Qureshi A.A.,
Giovannucci E.L.,
Cho E.
Publication year - 2015
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.13463
Subject(s) - psoriasis , gallstones , medicine , psoriatic arthritis , body mass index , cholecystectomy , relative risk , prospective cohort study , cohort , odds ratio , population , cohort study , risk factor , confidence interval , dermatology , environmental health
Summary Background Metabolic syndrome has been associated with both gallstones and psoriasis, suggesting a potential biological linkage between gallstones and psoriasis. However, the association between gallstones and psoriasis has not yet been studied. Objectives To investigate the association between gallstones and psoriasis. Methods This was a prospective cohort study [Nurses’ Health Study II (1991–2005)]. Women aged 25–42 years who were free from psoriasis at baseline and who responded to a 2005 follow‐up questionnaire regarding their diagnosis of psoriasis were included ( n = 89 230). The relative risk ( RR ) of developing psoriasis or psoriatic arthritis (PsA), which were self‐reported and validated by supplemental questionnaires, was measured. Results In this population, 2206 participants had gallstones confirmed by a history of cholecystectomy at baseline. A total of 642 individuals had a diagnosis of incident psoriasis, of whom 157 had concomitant PsA. After adjusting for known risk factors of psoriasis besides body mass index ( BMI ), a baseline history of cholecystectomy‐confirmed gallstones was associated with increased risk of psoriasis [multivariate‐adjusted RR 2·20, 95% confidence interval ( CI ) 1·56–3·10] and concomitant PsA (multivariate‐adjusted RR 4·41, 95% CI 2·70–7·18). After additionally adjusting for BMI , the fully adjusted RR s associated with a history of cholecystectomy‐confirmed gallstones were 1·70 (95% CI 1·20–2·41) for psoriasis and 2·96 (95% CI 1·80–4·89) for PsA. Conclusions Personal history of gallstones was associated with an increased risk of psoriasis and PsA, independent of obesity, in a cohort of U.S. women.