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Severe flucloxacillin‐induced acute generalized exanthematous pustulosis ( AGEP ), with toxic epidermal necrolysis ( TEN )‐like features: does overlap between AGEP and TEN exist? Clinical report and review of the literature
Author(s) -
Hattem S.,
Beerthuizen G.I.,
Kardaun S.H.
Publication year - 2014
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.13152
Subject(s) - toxic epidermal necrolysis , acute generalized exanthematous pustulosis , flucloxacillin , medicine , dermatology , drug reaction , drug , pharmacology , staphylococcus aureus , genetics , biology , bacteria
Summary Acute generalized exanthematous pustulosis ( AGEP ) and Stevens–Johnson syndrome ( SJS )/toxic epidermal necrolysis ( TEN ) are rare but severe cutaneous adverse drug reactions. Especially in TEN , large areas of the skin and mucosae may become detached. Although AGEP and SJS / TEN are distinct entities with a different clinical picture, pathogenesis, prognosis and treatment, they may share some features, raising the hypothesis of overlap between both entities. We present a severe case of AGEP , caused by flucloxacillin, clinically presenting with TEN ‐like features and pronounced systemic symptoms with haemodynamic and respiratory instability. Furthermore, we present a review of the literature on cases of AGEP with features resembling SJS / TEN or a supposed overlap with SJS / TEN .