Severe flucloxacillin‐induced acute generalized exanthematous pustulosis ( AGEP ), with toxic epidermal necrolysis ( TEN )‐like features: does overlap between AGEP and TEN exist? Clinical report and review of the literature

Summary Acute generalized exanthematous pustulosis ( AGEP ) and Stevens–Johnson syndrome ( SJS )/toxic epidermal necrolysis ( TEN ) are rare but severe cutaneous adverse drug reactions. Especially in TEN , large areas of the skin and mucosae may become detached. Although AGEP and SJS / TEN are distinct entities with a different clinical picture, pathogenesis, prognosis and treatment, they may share some features, raising the hypothesis of overlap between both entities. We present a severe case of AGEP , caused by flucloxacillin, clinically presenting with TEN ‐like features and pronounced systemic symptoms with haemodynamic and respiratory instability. Furthermore, we present a review of the literature on cases of AGEP with features resembling SJS / TEN or a supposed overlap with SJS / TEN .