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Early‐onset acral basal cell carcinomas in Gorlin syndrome
Author(s) -
Torrelo A.,
Vicente A.,
Navarro L.,
Planaguma M.,
Bueno E.,
GonzálezSarmiento R.,
HernándezMartín A.,
NogueraMorel L.,
Requena L.,
Colmenero I.,
Parareda A.,
GonzálezEnseñat M.A.,
Happle R.
Publication year - 2014
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.13118
Subject(s) - medicine , humanities , library science , art , computer science
Summary Two patients are reported in whom early‐onset, distal papules with a histopathological diagnosis of basal cell carcinoma were the first manifestation of Gorlin syndrome ( GS ). These lesions showed no progression and remained stable through follow‐up. Two different PTCH 1 gene mutations were detected in the two patients, and thus a phenotype–genotype correlation of this manifestation of GS was not possible.