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Safety of biological therapies for psoriasis: effects on reproductive potential and outcomes in male and female patients
Author(s) -
Yiu Z.Z.N.,
Griffiths C.E.M.,
Warren R.B.
Publication year - 2014
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.13060
Subject(s) - psoriasis , medicine , adverse effect , fertility , pregnancy , clinical trial , intensive care medicine , pediatrics , obstetrics , population , dermatology , biology , genetics , environmental health
Summary The effects of biological therapies for psoriasis on pregnancy outcomes and lactation, and male fertility and mutagenicity are common concerns in the clinical setting. There is relatively little evidence to guide the clinician and patient. Here, we review the safety profile of the commonly used biological therapies for psoriasis in individuals of reproductive potential. Safety data were derived from large‐scale registries, adverse event reporting databases, clinical trials and case reports. We assessed the effect of each therapy on adverse pregnancy outcomes including congenital malformations, and lactation with maternal administration, and male fertility and potential mutagenicity with paternal administration. We provide applicable guidance to inform clinician and patient before and after conception.