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Actinic damage on the back is significantly determined by MC1R variants and previous sun exposure compared with other body sites in a multivariate analysis
Author(s) -
Wendt J.,
Rauscher S.,
BurgstallerMühlbacher S.,
Roka F.,
Fae I.,
Fischer G.,
Pehamberger H.,
Okamoto I.
Publication year - 2014
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.12994
Subject(s) - medicine , multivariate analysis , dorsum , logistic regression , dermatology , multivariate statistics , eye color , risk factor , melanoma , population , pathology , genetics , biology , anatomy , environmental health , cancer research , statistics , mathematics , gene
Summary Background Only recently, site‐dependent associations of actinic damage with melanoma were identified in our study population. Objectives To elucidate the diverse aetiologies for actinic damage at different body sites. Methods We performed multivariate logistic regression analyses to identify independent risk factors for actinic damage on the face, hands and the back in 2112 participants of central European origin. Results For actinic damage on the face, age was the only risk factor that remained consistently significant in a multivariate analysis, whereas actinic damage on the back was predominantly associated with number of sunburns, freckles in childhood, holiday weeks and male sex. Moreover, we identified a particular significance of MC 1R variants and dorsal actinic skin damage. Conclusions The particular effect of MC 1R variants and sun exposure during recreational time on dorsal actinic damage indicates that actinic damage on the back is more informative regarding susceptibility to sunlight and past sun exposure associated with melanoma risk.