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Psoriasis associated with idiopathic CD 4+ T ‐cell lymphopenia: a regulatory T ‐cell defect?
Author(s) -
Baroudjian B.,
Viguier M.,
Battistella M.,
Beneton N.,
Pagès C.,
Gener G.,
Bégon E.,
Bachelez H.
Publication year - 2014
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.12922
Subject(s) - psoriasis , lymphocytopenia , foxp3 , medicine , immunology , disease , immune system , immunodeficiency , t cell , dermatology , pathology , lymphocyte
Summary Idiopathic CD 4 + lymphocytopenia ( ICL ) is a rare immunodeficiency syndrome of unknown origin for which the increased risks of opportunistic infections and of malignancies have been well established; however, skin dysimmune diseases, including psoriasis, have been scarcely reported up to now. We report herein the severe course of psoriasis in four patients with ICL , and show evidence for a defect in the skin recruitment of regulatory CD 4 + F ox P 3 + T cells. These data raise the apparent paradigm of the occurrence of a severe immunomediated disease together with a profound T ‐cell defect, a model that might also apply to other immune deficiencies associated with psoriasis.