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The association of host and genetic melanoma risk factors with B reslow thickness in the W estern A ustralian M elanoma H ealth S tudy
Author(s) -
Cadby G.,
Ward S.V.,
Cole J.M.,
Moses E.K.,
Millward M.,
Palmer L.J.
Publication year - 2014
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.12829
Subject(s) - breslow thickness , melanoma , medicine , association (psychology) , dermatology , risk factor , cancer , psychology , cancer research , sentinel lymph node , breast cancer , psychotherapist
Summary Background Breslow thickness is the most important predictor of survival in localized malignant melanoma. A number of melanoma risk factors have been shown to be associated with B reslow thickness; however, the role of genetic loci has been little investigated to date. Objectives To investigate the association of known melanoma susceptibility genetic loci with B reslow thickness. Methods Participants were 800 individuals from the W estern A ustralian M elanoma H ealth S tudy who completed a questionnaire and provided a DNA sample. Genetic association analyses between single‐nucleotide polymorphisms ( SNP s) from 15 candidate melanoma susceptibility genes and B reslow thickness were performed, controlling for relevant covariates. Results Older age at diagnosis and absence of naevi were associated with increased B reslow thickness. Following adjustment for multiple testing, no SNP s were significantly associated with B reslow thickness. Conclusions Associations observed between B reslow thickness and age and naevi reinforce current knowledge. Some evidence of shared genetic determinants between melanoma risk and B reslow thickness was found. Further studies are required to confirm this finding.