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Inflammasome activation and vitiligo/nonsegmental vitiligo progression
Author(s) -
Marie J.,
Kovacs D.,
Pain C.,
Jouary T.,
Cota C.,
Vergier B.,
Picardo M.,
Taieb A.,
Ezzedine K.,
CarioAndré M.
Publication year - 2014
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.12691
Subject(s) - vitiligo , medicine , dermatology , art history , library science , art , computer science
Summary Background Polymorphisms of NLR (nucleotide‐binding domain and leucine rich repeat containing) family, pyrin domain containing protein 1 ( NLRP 1) have been found in patients with vitiligo/nonsegmental vitiligo ( NSV ), and increased NLRP 1 expression has been detected in the leading edge of lesional skin biopsies. Objectives To evaluate the presence and intensity of NLRP 1 immunostaining in lesional and perilesional skin of patients with vitiligo/ NSV and to search for possible correlations between NLRP 1 and interleukin ( IL )‐1β expression, lymphocytic infiltrates and disease activity. Methods Of 14 consecutive vitiligo/ NSV patients, eight had active disease [ V itiligo E uropean T ask F orce ( VETF ) spreading score +1 to +5], one patient had stable disease and five patients had regressive disease ( VETF spreading score −1 to −3). We performed immunostaining for NLRP 1, B and T lymphocytes, IL ‐1β and kallikrein 7 on lesional and perilesional vitiligo skin. Results NLRP 1 and IL ‐1β immunostaining in perilesional vitiligo/ NSV skin was significantly associated with progressive disease ( P = 0·009 and 0·04, respectively) and performed better than the simple detection of lymphocytic infiltrates. Conclusions Our findings suggest that markers of the NLRP 1 inflammasome could be a useful test for assessing disease activity in addition to the detection of inflammatory infiltrates in the progressing margins of vitiligo/ NSV lesions.