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Systemic involvement of acute generalized exanthematous pustulosis: a retrospective study on 58 patients
Author(s) -
Hotz C.,
ValeyrieAllanore L.,
Haddad C.,
Bouvresse S.,
Ortonne N.,
Duong T.A.,
IngenHouszOro S.,
Roujeau J.C.,
Wolkenstein P.,
Chosidow O.
Publication year - 2013
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.12502
Subject(s) - acute generalized exanthematous pustulosis , medicine , dermatology , retrospective cohort study , pustulosis , surgery , osteomyelitis , osteitis
Summary Background Acute generalized exanthematous pustulosis ( AGEP ) is a severe cutaneous adverse reaction characterized by rash with sterile pustules, high fever and elevated circulating neutrophil counts. Objectives To investigate the frequency and clinical features of AGEP systemic involvement. Methods This retrospective study included all patients hospitalized in our department between 2000 and 2010 with a discharge diagnosis of AGEP . Patients had to fulfil the following criteria: (i) a specific Euro SCAR score > 4 and (ii) biological and radiological work‐up available. Results Among the 58 patients enrolled, 10 had at least one systemic involvement: hepatic function test results were abnormal for seven; six had renal insufficiency; two developed acute respiratory distress, with one patient's bronchoalveolar lavage fluid containing many neutrophils but no microorganisms; one was agranulocytotic. Mean peripheral neutrophil counts and mean C‐reactive protein levels were elevated significantly in patients with systemic involvement. Amoxicillin rechallenge and hospitalization duration were associated with systemic involvement. AGEP systemic involvement was observed in 17% of cases studied, including liver, kidney, bone‐marrow and lung involvement. Outcomes were favourable after drug withdrawal, and symptomatic and topical steroid treatments. Conclusions The neutrophil count–systemic involvement association may suggest a role for neutrophils in AGEP systemic involvement. Physicians should be aware of the possibility of systemic involvement in AGEP and should actively look for signs of extracutaneous reactions.