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Factors associated with the relapse of infantile haemangiomas in children treated with oral propranolol
Author(s) -
Ahogo C.K.,
Ezzedine K.,
Prey S.,
Colona V.,
Diallo A.,
Boralevi F.,
Taïeb A.,
LéautéLabrèze C.
Publication year - 2013
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.12432
Subject(s) - medicine , propranolol , infantile hemangioma , retrospective cohort study , observational study , single center , pediatrics , first line treatment , multivariate analysis , surgery , chemotherapy
Summary Background Although propranolol has become the first‐line therapy for infantile haemangiomas ( IH s), no study has yet investigated factors associated with the risk of relapse in children with IH treated with propranolol after cessation of treatment. Objectives To compare factors associated with the risk of relapse in children with IH treated with oral propranolol. Methods We conducted a single‐centre retrospective observational study. All files and photographs of patients with IH aged 5 months or less at the time of treatment initiation, and who were seen between 1 J une 2008 and 31 D ecember 2011 at the N ational R eference C enter for rare skin diseases of B ordeaux, were retrospectively reviewed. Results In total 158 children were included, of whom 118 had not relapsed and 40 had relapsed. Fifty‐two patients were boys and 106 were girls (male : female ratio 1 : 2), and 19 had a segmental IH (12%). When conducting multivariate analysis, only IH s with a deep component and those with segmental distribution were independently associated with relapse. Conclusions Our study shows that segmental IH s, as well as haemangiomas with a deeper component, are more at risk of relapse and should thus indicate closer follow‐up after treatment interruption, and/or longer treatment.