Premium
Network meta‐analysis of the outcome ‘participant complete clearance’ in nonimmunosuppressed participants of eight interventions for actinic keratosis: a follow‐up on a C ochrane review
Author(s) -
Gupta A.K.,
Paquet M.
Publication year - 2013
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.12343
Subject(s) - imiquimod , actinic keratosis , medicine , cryotherapy , placebo , psychological intervention , meta analysis , dermatology , randomized controlled trial , surgery , pathology , alternative medicine , psychiatry , basal cell
Summary The conclusions of pairwise meta‐analyses of interventions for actinic keratosis ( AK ) are limited due to the lack of direct comparison between some interventions. Consequently, we performed a network meta‐analysis for eight treatments [5‐aminolaevulinic acid ( ALA )‐photodynamic therapy ( PDT ), cryotherapy, diclofenac 3% in 2·5% hyaluronic acid ( DCF / HA ), 5‐fluorouracil (5‐ FU ) 0·5% or 5·0%, imiquimod ( IMI ) 5%, ingenol mebutate ( IMB ) 0·015–0·05%, methyl aminolaevulinate ( MAL )‐ PDT and placebo/vehicle (including placebo‐ PDT )] to determine their relative efficacies. As part of a prior C ochrane systematic review, different databases and grey literature were searched for randomized controlled trials up to A pril 2012. The inclusion criteria were parallel‐group studies with nonimmunosuppressed participants: (i) reporting ‘participant complete clearance’ and (ii) comparing at least two of the interventions. Thirty‐two publications met the criteria and they included the following number of individual or pooled studies ( n ) and total number of participants ( N ) for the different interventions: 5‐ FU 0·5% ( n = 4, N = 169), 5‐ FU 5·0% ( n = 2, N = 44), ALA ‐ PDT ( n = 6, N = 739), cryotherapy ( n = 2, N = 174), DCF / HA ( n = 5, N = 299), IMI ( n = 14, N = 1411), IMB ( n = 3, N = 560), MAL ‐ PDT ( n = 7, N = 557) and placebo ( n = 32, N = 2520). Network analyses using a random‐effects Bayesian model were carried out with the software ADDIS v1.16.1. The interventions were ranked as follows based on calculated probabilities and odd ratios: 5‐ FU > ALA ‐ PDT ≈ IMI ≈ IMB ≈ MAL ‐ PDT > cryotherapy > DCF/HA > placebo. This efficacy ranking was obtained based on the current available data on ‘participant complete clearance’ from randomized controlled trials and the analysis model used. However, several other factors should also be considered when prescribing a treatment for AK .