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Genetic associations of psoriasis in a Pakistani population
Author(s) -
Shaiq P.A.,
Stuart P.E.,
Latif A.,
Schmotzer C.,
Kazmi A.H.,
Khan M.S.,
Azam M.,
Tejasvi T.,
Voorhees J.J.,
Raja G.K.,
Elder J.T.,
Qamar R.,
Nair R.P.
Publication year - 2013
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/bjd.12313
Subject(s) - raja , population , medicine , library science , sociology , media studies , demography , paleontology , computer science , biology
Summary Background Genetic predisposition to psoriasis, an inflammatory skin disease affecting 0·2–4% of the world population, is well established. Thus far, 41 psoriasis susceptibility loci reach genome‐wide significance ( P ≤ 5 × 10 −8 ). Identification of genetic susceptibility loci in diverse populations will help understand the underlying biology of psoriasis susceptibility. Objectives The primary objective of this study was to examine psoriasis susceptibility associations previously reported in C hinese and caucasian populations in a P akistani cohort. Methods Blood samples and phenotype data were collected from psoriasis cases and controls in I slamabad, P akistan. DNA was isolated and genotypes of selected susceptibility markers were determined. The data were analysed using χ 2 tests or logistic regression for psoriasis association. Results HLA ‐ C w6 showed the strongest association [odds ratio ( OR ) 2·43, P = 2·3 × 10 −12 ]. HLA ‐ C w1 showed marginally significant association ( OR 1·66, P = 0·049), suggesting that the HLA ‐ C w1‐ B 46 risk haplotype may be present in the P akistani population. Three other loci ( IL 4 / IL 13 , NOS 2 , TRAF 3 IP 2 ) showed nominally significant association ( P < 0·05). Conclusions HLA ‐ C w6 is strongly associated with psoriasis susceptibility in the P akistani population, as has been found in every other population studied. In addition, HLA ‐ C w1 showed marginal association, reflecting the relative geographical proximity and thus likely genetic relatedness to other populations in which the HLA ‐ C w1‐ B 46 haplotype is known to be associated. A larger cohort and a denser marker set will be required for further analysis of psoriasis associations in the S outh A sian population.