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An International Society of Bipolar Disorders task force report: Precursors and prodromes of bipolar disorder
Author(s) -
Faedda Gianni L.,
Baldessarini Ross J.,
Marangoni Ciro,
Bechdolf Andreas,
Berk Michael,
Birmaher Boris,
Conus Philippe,
DelBello Melissa P.,
Duffy Anne C.,
Hillegers Ma H. J.,
Pfennig Andrea,
Post Robert M.,
Preisig Martin,
Ratheesh Aswin,
Salvatore Paola,
Tohen Mauricio,
Vázquez Gustavo H.,
Vieta Eduard,
Yatham Lakshmi N.,
Youngstrom Eric A.,
Van Meter Anna,
Correll Christoph U.
Publication year - 2019
Publication title -
bipolar disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.285
H-Index - 129
eISSN - 1399-5618
pISSN - 1398-5647
DOI - 10.1111/bdi.12831
Subject(s) - hypomania , bipolar disorder , mania , prodrome , psychiatry , panic disorder , anxiety , prospective cohort study , medicine , psychology , family history , clinical psychology , mood , psychosis
Objectives To clarify the clinical features preceding the onset of bipolar disorder (BD) has become a public health priority for the prevention of high morbidity and mortality. BD remains frequently under‐ or misdiagnosed, and under‐ or mistreated, often for years. Methods We assessed the predictive value of precursors and prodromes of BD. We assessed precursors of first‐lifetime manic or hypomanic episodes with/without mixed features in retrospective and prospective studies. The task force evaluated and summarized separately assessments of familial risk, premorbid personality traits, retrospective, and prospective studies. Results Cyclothymic features, a family history of BD, retrospectively reported attenuated manic symptoms, prospectively identified subthreshold symptoms of hypomania, recurrence of depression, panic anxiety and psychotic features, have been identified as clinical precursors of BD. The prodromal symptoms like [hypo]mania often appears to be long enough to encourage early identification and timely intervention. Conclusions The predictive value of any risk factor identified remains largely unknown. Prospective controlled studies are urgently needed for prevention and effective treatment.