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Longitudinal brain functional changes between mania and euthymia in bipolar disorder
Author(s) -
AlonsoLana Silvia,
Moro Noemí,
McKenna Peter J.,
Sarró Salvador,
Romaguera Anna,
Monté Gemma C.,
Maristany Teresa,
Goikolea José M.,
Vieta Eduard,
Salvador Raymond,
PomarolClotet Edith
Publication year - 2019
Publication title -
bipolar disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.285
H-Index - 129
eISSN - 1399-5618
pISSN - 1398-5647
DOI - 10.1111/bdi.12767
Subject(s) - precuneus , psychology , dorsolateral prefrontal cortex , bipolar disorder , neuroscience , ventromedial prefrontal cortex , posterior parietal cortex , mania , functional magnetic resonance imaging , prefrontal cortex , cognition
Objectives While widespread cortical and subcortical brain functional abnormalities have been found in bipolar disorder, the changes that take place between illness phases and recovery are less clearly documented. Only a small number of longitudinal studies of manic patients, in particular, have been carried out. Methods Twenty‐six bipolar patients underwent fMRI during performance of the n‐back working memory task when manic and again after recovery. Twenty‐six matched healthy controls were also scanned on two occasions. Task‐related activations and de‐activations were examined. Results When manic, the patients showed clusters of significantly reduced activation in the left dorsolateral prefrontal cortex (DLPFC)/precentral cortex and the parietal cortex/superior precuneus bilaterally. They also showed failure of de‐activation in the ventromedial frontal cortex (vmPFC). After recovery, activation in the left DLPFC/precentral cortex and in the bilateral parietal cortex/superior precuneus clusters increased significantly. However, failure of de‐activation remained present in the vmPFC. Conclusions Recovery from mania is associated with normalization of DLPFC and parietal hypoactivation, but not with vmPFC failure of de‐activation, which accordingly appears to represent a trait abnormality in the disorder.