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Association between the zinc finger protein 804A ( ZNF 804A ) gene and the risk of schizophrenia and bipolar I disorder across diagnostic boundaries
Author(s) -
Baek Ji Hyun,
Ha Kyooseob,
Kim Yongkang,
Yang So Yung,
Cho EunYoung,
Choi Yujin,
Ryu Seunghyong,
Lee YuSang,
Park Taesung,
Hong Kyung Sue
Publication year - 2017
Publication title -
bipolar disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.285
H-Index - 129
eISSN - 1399-5618
pISSN - 1398-5647
DOI - 10.1111/bdi.12493
Subject(s) - single nucleotide polymorphism , snp , bipolar disorder , candidate gene , schizophrenia (object oriented programming) , genetic association , genetics , psychosis , logistic regression , population , biology , genotype , oncology , gene , medicine , psychiatry , environmental health , lithium (medication)
Objectives In this study, we aimed to determine the role of genetic variations within the zinc finger protein 804A ( ZNF 804A ) gene, a candidate for a psychosis risk‐conferring gene, in the development of schizophrenia ( SZ ) and bipolar disorder ( BP ) in the Korean population. Methods A total of 921 patients with SZ , bipolar I ( BP ‐I) and II ( BP ‐ II ) disorder, and 502 control subjects participated in the study. Twenty‐one tag single nucleotide polymorphisms ( SNP s) across the genomic region of ZNF 804A and seven reference SNP s based on previous reports were genotyped. We applied logistic regression analyses under additive, dominant and recessive models. Results Fifteen of the 28 SNP s showed a nominally significant association with at least one diagnostic group. However, none of these associations remained significant after false discovery rate ( FDR ) correction. As the trend of association was observed mostly in SZ and BP ‐I with similar patterns, we performed a post hoc analysis for the combined SZ and BP ‐I group. Five SNP s (rs2369595, rs6755404, rs10931156, rs12476147 and rs1366842) showed a significant association with an FDR ‐corrected P of <.05. Conclusions This study supports a possible role of ZNF 804A in the common susceptibility of major psychoses, and identified additional candidate variants of the gene in the Korean population.