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Objectives  Recent genome‐wide association studies ( GWAS s) have identified numerous putative genetic polymorphisms associated with bipolar disorder ( BD ) and/or schizophrenia ( SC ). We hypothesized that a portion of these polymorphisms would also be associated with  BD  in the Latino American population. To identify such regions, we tested previously identified genetic variants associated with  BD  and/or  SC  and ancestral haploblocks containing these single nucleotide polymorphisms ( SNP s) in a sample of Latino subjects with  BD .    Methods  A total of 2254 Latino individuals were genotyped for 91  SNP s identified in previous  BD  and/or  SC GWAS s, along with selected  SNP s in strong linkage disequilibrium with these markers. Family‐based single marker and haplotype association testing was performed using the  PBAT  software package. Empirical  P ‐values were derived from 10 000 permutations.    Results  Associations of eight  a priori   GWAS SNP s with  BD  were replicated with nominal ( P ≤.05) levels of significance. These included  SNP s within nuclear factor I A (  NFIA  ), serologically defined colon cancer antigen 8 (  SDCCAG 8 ), lysosomal associated membrane protein 3 (  LAMP 3 ), nuclear factor kappa B subunit 1 (  NFKB 1 ), major histocompatibility complex, class I, B (  HLA ‐B ) and 5′‐nucleotidase, cytosolic II (  NT 5C2 ) and  SNP s within intragenic regions microRNA 6828 (  MIR 6828 ) — solute carrier family 7 member 14 (  SLC 7A14 ) and sonic hedgehog (  SHH  ) — long intergenic non‐protein coding RNA 1006 (  LINC 01006 ). Of the 76 ancestral haploblocks that were tested for associations with  BD , our top associated haploblock was located in   LAMP 3 ; however, the association did not meet statistical thresholds of significance following Bonferroni correction.    Conclusions  These results indicate that some of the gene variants found to be associated with  BD  or  SC  in other populations are also associated with  BD  risk in Latinos. Variants in six genes and two intragenic regions were associated with  BD  in our Latino sample and provide additional evidence for overlap in genetic risk between  SC  and  BD .

Replication of genome‐wide association study ( GWAS ) susceptibility loci in a Latino bipolar disorder cohort