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The neurocognitive profile of mood disorders – a review of the evidence and methodological issues
Author(s) -
Porter Richard J,
Robinson Lucy J,
Malhi Gin S,
Gallagher Peter
Publication year - 2015
Publication title -
bipolar disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.285
H-Index - 129
eISSN - 1399-5618
pISSN - 1398-5647
DOI - 10.1111/bdi.12342
Subject(s) - neurocognitive , psychology , cognition , mood , bipolar disorder , clinical psychology , mood disorders , major depressive disorder , depression (economics) , psychiatry , anxiety , economics , macroeconomics
Objectives Cognitive abnormalities are an established part of the symptomatology of mood disorders. However, questions still exist regarding the exact profile of these deficits in terms of the domains most affected, their origins, and their relationship to clinical subtypes. This review aims to examine the current state of the evidence and to examine ways in which the field may be advanced. Methods Studies examining cognitive function in bipolar disorder ( BD ) and unipolar major depression ( MDD ) were examined. Given the number and variability of such studies, particular attention was paid to meta‐analyses and to meta‐regression analyses which examined the possible mediators of cognitive impairment. Results Meta‐analyses are available for MDD and BD in both depression and euthymia. Several analyses examine mediators. Results do not support the presence of domain specific deficits but rather a moderate deficit across a range of domains in BD and in MDD . The data on clinical mediators is inconsistent, even with regard to the effect of mood state. Conclusions A two‐tiered approach, with the broad‐based application of standardized measures on a large‐scale, and the refined application of theoretically driven experimental development would significantly further our understanding of neurocognitive processing in mood disorder.