Premium
Comorbid alcohol dependence disorder may be related to aldehyde dehydrogenase 2 ( ALDH 2 ) and alcohol dehydrogenase 1B ( ADH 1B ) in bipolar II disorder, but only to ALDH 2 in bipolar I disorder, in Han Chinese
Author(s) -
Chang YunHsuan,
Lee ShengYu,
Wang TzuYun,
Chen ShiouLan,
Tzeng NianSheng,
Chen Po See,
Lee I Hui,
Chen Kao Chin,
Huang SanYuan,
Yang Yen Kuang,
Ko HuiChen,
Lu RuBand
Publication year - 2015
Publication title -
bipolar disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.285
H-Index - 129
eISSN - 1399-5618
pISSN - 1398-5647
DOI - 10.1111/bdi.12313
Subject(s) - aldehyde dehydrogenase , alcohol dehydrogenase , alcohol , chemistry , enzyme , biochemistry
Objectives A high prevalence rate of bipolar disorder ( BP ) comorbid with alcohol dependence ( AD ) ( BP + AD ) in Western patients with BP has been reported, but whether this is true for Han Chinese with BP is uncertain. We explored the prevalence of BP + AD in a Han Chinese population with BP , and investigated the effect of alcohol‐metabolizing genotypes on bipolar I disorder ( BP ‐I) + AD and bipolar II disorder ( BP ‐ II ) + AD . Methods Healthy controls ( HC s) (n = 672) and 18‐ to 65‐year‐old patients with BP ( BP ‐I: n = 530; BP ‐ II : n = 788) were recruited. Patients with any other major or minor mental illnesses, neurological disorders, or organic mental disorders were excluded. A polymerase chain reaction and restriction fragment length polymorphism analysis was used to determine genotypes for alcohol dehydrogenase 1B ( ADH 1B) and aldehyde dehydrogenase 2 ( ALDH 2), two alcohol‐metabolizing enzymes. Results AD comorbidity rates were 11.7% with BP ‐I and 17.1% with BP ‐ II . Significantly fewer patients with BP not comorbid with AD ( BP – AD ) carried the AHD 1B*1 allele than did the HC s. Logistic regression analysis showed a main effect of ALDH 2*1/*1 only in the BP ‐I– AD group. In BP + AD patients, logistic regression analysis showed main effects of ALDH 2*1/*1 and ADH 1B*1/*1 only in the BP ‐ II + AD group. Conclusions Having BP ‐ II + AD may be related to ALDH 2 and ADH 1B , but having BP ‐I+ AD may be related only to ALDH 2 . We conclude that ALDH 2 and ADH 1B have different effects in Han Chinese patients with BP ‐I+ AD and BP ‐ II + AD .