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Reduced activities of phospholipases A 2 in platelets of drug‐naïve bipolar disorder patients
Author(s) -
Ikenaga Eliza Hiromi,
Talib Leda Leme,
Ferreira Aline Siqueira,
MachadoVieira Rodrigo,
Forlenza Orestes Vicente,
Gattaz Wagner F
Publication year - 2015
Publication title -
bipolar disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.285
H-Index - 129
eISSN - 1399-5618
pISSN - 1398-5647
DOI - 10.1111/bdi.12229
Subject(s) - platelet , medicine , extracellular , endocrinology , phospholipase a , intracellular , phospholipase , calcium , enzyme , disease , drug , calcium in biology , bipolar disorder , psychology , phospholipase a2 , pharmacology , chemistry , biochemistry , lithium (medication)
Objective Phospholipases A 2 (PLA 2 ) comprise a family of hydrolytic enzymes that cleave membrane phospholipids and play a key role in cellular homeostasis. Alterations in enzymatic activity have been hypothesized in bipolar disorder (BD). Recent studies suggest that PLA 2 activity in platelets may reflect PLA 2 activity in the brain. The aim of this study was to determine PLA 2 activity in platelets of BD patients. Methods We determined the activity of PLA 2 subtypes [extracellular, calcium‐dependent PLA 2 (sPLA 2 ), intracellular, calcium‐dependent PLA 2 (cPLA 2 ), and intracellular, calcium‐independent PLA 2 (iPLA 2 )] by a radioenzymatic method in platelets from 20 patients with BD (15 drug‐naïve and five drug‐free) and from 16 age‐ and gender‐matched healthy controls. Results We found that iPLA 2 , cPLA 2 , and sPLA 2 activities were lower in drug‐naïve patients with BD when compared to the control group (p = 0.017, p < 0.001, and p < 0.001, respectively). Conclusions Reduced PLA 2 activity at the early stage of BD may disrupt brain function and increase the risk for the disease. Moreover, epidemiological studies show that patients with BD have a fivefold increased risk for developing Alzheimer's disease. Because patients with Alzheimer's disease also have reduced PLA 2 activity, the present finding of reduced PLA 2 in the BD group may be related to the risk factor for these individuals developing Alzheimer's disease in advanced age.