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Brain electrical source imaging in manic and depressive episodes of bipolar disorder
Author(s) -
Painold Annamaria,
Faber Pascal L,
Milz Patricia,
Reininghaus Eva Z,
Holl Anna K,
Letmaier Martin,
PascualMarqui Roberto D,
Reininghaus Bernd,
Kapfhammer HansPeter,
Lehmann Dietrich
Publication year - 2014
Publication title -
bipolar disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.285
H-Index - 129
eISSN - 1399-5618
pISSN - 1398-5647
DOI - 10.1111/bdi.12198
Subject(s) - bipolar disorder , electroencephalography , psychology , mood , audiology , mania , brain activity and meditation , neuroscience , prefrontal cortex , major depressive disorder , psychiatry , cognition , medicine
Objective Bipolar disorder (BD) electroencephalographic (EEG) studies have reported varying results. The present study compared EEG in BD during manic and depressive episodes, using brain electrical source imaging [standardized low‐resolution electromagnetic tomography (sLORETA)] to assess the cortical spatial distribution of the sources of EEG oscillation frequencies. Methods Two independent datasets (a total of 95 patients with bipolar I disorder, of whom 59 were female) were analyzed. Dataset #1 comprised 14 patients in a manic as well as a depressive episode. Dataset #2 comprised 26 patients in a manic episode and 55 patients in a depressive episode. From the head surface‐recorded EEG, sLORETA cortical activity was computed in eight EEG frequency bands, and compared between mood states in both datasets. The results from the two datasets were combined using conjunction analysis. Results Conjunction analysis yielded significant differences between mood states: In manic compared to depressive states, patients had lesser theta frequency band activity (right‐hemispheric lateral lower prefrontal and anterior temporal, mainly Brodmann areas 13, 38, and 47), and greater beta‐2 and beta‐3 frequency band activity (extended bilateral prefrontal‐to‐parietal, mainly Brodmann area 6, and the cingulate). Conclusions The spatial organization of the brain's electrical oscillations differed in patients with BD between manic and depressive mood states. The brain areas implementing the main functions that show opposing abnormalities during manic and depressive episodes were affected by unduly increased or decreased activity (beta or theta). The discussion considers that facilitating (beta) or inhibiting (theta) electrical activity can in either case result in behavioral facilitation or inhibition, depending on the function of the brain area.