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Resistant bipolar depressive disorder: case analysis of adjunctive transcranial magnetic stimulation efficiency in medical comorbid conditions
Author(s) -
Zendjidjian Xavier Yves,
Lodovighi MarcAntoine,
Richieri Raphaelle,
Guedj Eric,
Boyer Laurent,
Dassa Daniel,
Lançon Christophe
Publication year - 2014
Publication title -
bipolar disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.285
H-Index - 129
eISSN - 1399-5618
pISSN - 1398-5647
DOI - 10.1111/bdi.12170
Subject(s) - university hospital , general hospital , psychiatry , bipolar disorder , psychology , medicine , humanities , art , pediatrics , family medicine , mood
There are controlled trials and meta-analyses (1) that provide support for repetitive transcranial magnetic stimulation (rTMS) having efficacy in the treatment of resistant depressive disorders. However, only one study has, to date, addressed this issue in patients with bipolar disorder without medical comorbidities (2) and the other recent studies do not mention comorbid status (3, 4). Yet, medical comorbidities are found in 59% of patients with bipolar disorder (5). Exploring the efficiency of rTMS in these patients is therefore of great importance, especially since comorbidities are known to complicate the clinical course of the illness, with evidence of increased rates of chronicity and non-recovery (6, 7). We report here a case of a patient with a history of multi-resistant bipolar depression and several medical comorbidities who responded to rTMS after unsuccessful trials of drug treatments.