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ED50 of propofol in combination with low‐dose sufentanil for intravenous anaesthesia in hysteroscopy
Author(s) -
Yu Jin,
Xiang Bo,
Song Yun,
Chen Hu,
Li Youchang,
Liu Chun
Publication year - 2019
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/bcpt.13280
Subject(s) - sufentanil , propofol , medicine , anesthesia , ed50 , pharmacokinetics , pharmacodynamics , loading dose , pharmacology , receptor
Objectives Sufentanil has favourable pharmacodynamic and pharmacokinetic properties as an opioid, and it is usually co‐administered with propofol as intravenous anaesthesia for hysteroscopic examination or therapeutic surgery. However, the optimal dosage of propofol when it is co‐administered with low‐dose sufentanil has not yet been established. This study was designed to find the median effective dose of propofol for intravenous anaesthesia when combined with low‐dose sufentanil. Methods Fifty‐four patients were enrolled and randomized into two groups in this prospective study. Sufentanil 0.2 μg/kg (Group A) or 0.1 μg/kg (Group B) was given intravenously before speculum placement. The initial propofol dose was set at 2 mg/kg and varied by 0.1 mg/kg according to the sequential allocation up‐and‐down rule designed by Dixon and Massey. Respiratory depression, duration of initial dose of propofol, total drug quantity administered and recovery time were recorded. Results The ED50 of propofol was 1.651 mg/kg (95% CI, 1.561‐1.722 mg/kg) in Group A and 1.991 mg/kg (95% CI, 1.902‐2.081 mg/kg) in Group B. The ED95 of propofol was 1.827 mg/kg (95% CI, 1.746‐2.236 mg/kg) in Group A and 2.153 mg/kg (95% CI, 2.070‐2.73 7 mg/kg) in Group B. The initial and total dosage of propofol in Group A were significantly lower than those in Group B, but the incidence of respiratory depression in Group A (26.67%) was significantly higher than that in Group B (4.17%). Conclusion The ED50 values for propofol when co‐administered with low‐dose sufentanil for intravenous anaesthesia in hysteroscopy were 1.651 mg/kg (sufentanil 0.2 μg/kg) and 1.991 mg/kg (sufentanil 0.1 μg/kg). ( www.chictr.org.cn , registration number: ChiCTR1900021224).