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Therapeutic Drug Monitoring of Teicoplanin in Haematological Malignancy Patients with Febrile Neutropenia and Optimizing Dosage Regimens
Author(s) -
Hu Sasa,
Wang Taotao,
You Haisheng,
Wei Shuangyu,
Song Hongjuan,
Zhang Tao,
Zhang Di,
Dong Yalin
Publication year - 2018
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/bcpt.13029
Subject(s) - cmin , medicine , teicoplanin , pharmacokinetics , pharmacodynamics , trough concentration , neutropenia , cmax , creatinine , therapeutic drug monitoring , gastroenterology , pharmacology , toxicity , vancomycin , biology , bacteria , genetics , staphylococcus aureus
This study used high‐performance liquid chromatography to measure 202 teicoplanin plasma trough concentrations ( C min ) in 114 haematological malignancy patients with febrile neutropenia. Patients were divided into two groups according to the mean initial dose ( MID ) over the first 3 days of treatment: (i) MID = 533.33 mg/day (loading dose group, 400 mg q12h for three doses followed by 400 mg qd, n = 62) and (ii) MID < 533.33 mg/day (unloaded or underloaded group, n = 52). During the first 3 days after treatment, the overall C min was higher in group 1 than in group 2 (10.96 ± 5.44 mg/L versus 6.31 ± 3.73 mg/L, mean ± S.D. ; p = 0.002), as was the qualifying rate of C min > 10 mg/L (54.5% versus 11.1%, p = 0.001), and the probability of C min < 5 mg/L was lower in group 1 than in group 2 (13.6% versus 40.7%, p = 0.037). After 3 days, the average C min and qualifying rates did not differ significantly between the two groups, and the average C min was <10 mg/L in both groups. Binary logistic regression analysis revealed that creatinine clearance ( p = 0.004) and MID ( p = 0.010) could affect C min during the first 3 days of treatment and that age ( p = 0.022) only could affect C min after 3 days. In conclusion, it is necessary to apply loading dose to achieve teicoplanin C min > 10 mg/L rapidly and, from a pharmacokinetic/pharmacodynamic perspective, 600 mg is recommended as loading and maintenance dose for these patients when AUC 24 /minimum inhibitory concentration > 345.