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Comparative Study of Genotoxicity Induced by Six Different PBDE s
Author(s) -
Pereira Lílian Cristina,
Souza Alecsandra Oliveira,
Meireles Gabriela,
FrancoBernardes Mariana Furio,
Tasso Maria Júlia,
Bruno Vítor,
Dorta Daniel Junqueira,
Oliveira Danielle Palma
Publication year - 2016
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/bcpt.12595
Subject(s) - decabromodiphenyl ether , genotoxicity , comet assay , micronucleus test , congener , chemistry , polybrominated biphenyls , toxicology , salmonella , diphenyl ether , population , environmental chemistry , dna damage , polybrominated diphenyl ethers , toxicity , biology , fire retardant , environmental health , biochemistry , pollutant , medicine , organic chemistry , genetics , dna , bacteria
Indiscriminate use of synthetic substances has led to environmental contamination and increasing human and animal exposure to harmful chemicals. Polybrominated flame retardants ( PBDE s), which serve as non‐covalent additives that enhance the safety of a variety of commercial and consumer goods, are an important class among potentially damaging synthetic substances. Its use is very common in developing countries, including Brazil. In theory, 209 different PBDE congeners exist, and many are currently being used during the manufacture of several products. Unfortunately, PBDE s are easily released from the original products, promptly reaching the environment. Knowledge about the toxicological power of these substances is still limited, which has prevented environmental and regulatory authorities from conducting adequate risk assessments. This research addresses the genotoxic and mutagenic potential of PBDE s. The effects of HepG2 cells and Salmonella typhimurium exposure to six main representatives of PBDE s, namely tetrabromodiphenyl ether ( BDE ‐47), pentabromodiphenyl ether ( BDE ‐99 and BDE ‐100), hexabromodiphenyl ether ( BDE ‐153 and BDE ‐154) and decabromodiphenyl ether ( BDE ‐209), were evaluated. The comet assay revealed that all the assessed BDE s exerted genotoxic effects but induced no micronuclei formation in HepG2 cells. These BDE s had no significant mutagenic effects on the Salmonella typhimurium strains TA 98 and TA 100. Taken together, the results of the genomic instability assays showed that PBDE s can represent a risk to the health of directly and indirectly exposed population, because the assessed BDE s induce genotoxic effects in the HepG2 cell line.