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The TRPA 1 Activator Allyl Isothiocyanate ( AITC ) Contracts Human Jejunal Muscle: Pharmacological Analysis
Author(s) -
Sandor Zsolt,
Dekany Andras,
Kelemen Dezsö,
Bencsik Timea,
Papp Robert,
Bartho Lorand
Publication year - 2016
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/bcpt.12574
Subject(s) - tetrodotoxin , allyl isothiocyanate , chemistry , antagonist , atropine , muscarinic acetylcholine receptor , pharmacology , biochemistry , biophysics , endocrinology , biology , receptor
Abstract The contractile effect of AITC (300 μM) on human jejunal longitudinal strips was inhibited by the TRPA 1 antagonist HC 030031 and atropine or scopolamine, but was insensitive to tetrodotoxin, purinoceptor antagonists or capsaicin desensitization. It is concluded that TRPA 1 activation stimulates a cholinergic mechanism in a tetrodotoxin‐resistant manner.