The  TRPA 1 Activator Allyl Isothiocyanate ( AITC ) Contracts Human Jejunal Muscle: Pharmacological Analysis | Zendy

Sandor Zsolt | Zendy; Dekany Andras | Zendy; Kelemen Dezsö | Zendy; Bencsik Timea | Zendy; Papp Robert | Zendy; Bartho Lorand | Zendy

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The TRPA 1 Activator Allyl Isothiocyanate ( AITC ) Contracts Human Jejunal Muscle: Pharmacological Analysis

Author(s) -

Sandor Zsolt,

Dekany Andras,

Kelemen Dezsö,

Bencsik Timea,

Papp Robert,

Bartho Lorand

Publication year - 2016

Publication title -

basic and clinical pharmacology and toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.805

H-Index - 90

eISSN - 1742-7843

pISSN - 1742-7835

DOI - 10.1111/bcpt.12574

Subject(s) - tetrodotoxin , allyl isothiocyanate , chemistry , antagonist , atropine , muscarinic acetylcholine receptor , pharmacology , biochemistry , biophysics , endocrinology , biology , receptor

The contractile effect of AITC (300 μM) on human jejunal longitudinal strips was inhibited by the TRPA 1 antagonist HC 030031 and atropine or scopolamine, but was insensitive to tetrodotoxin, purinoceptor antagonists or capsaicin desensitization. It is concluded that TRPA 1 activation stimulates a cholinergic mechanism in a tetrodotoxin‐resistant manner.

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