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Is Minocycline an Antiviral Agent? A Review of Current Literature
Author(s) -
Nagarakanti Sandhya,
Bishburg Eliahu
Publication year - 2016
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/bcpt.12444
Subject(s) - minocycline , tetracycline , acne , drug , medicine , periodontitis , human immunodeficiency virus (hiv) , in vitro , pharmacology , antibiotics , virus , virology , immunology , microbiology and biotechnology , biology , dermatology , biochemistry
Abstract Minocycline is a second‐generation semi‐synthetic derivative of tetracycline and has well‐known anti‐bacterial effects. The drug possesses anti‐inflammatory, anti‐oxidant, anti‐apoptotic and immunomodulatory effects. The drug is widely used in bacterial infections and non‐infectious conditions such as acne, dermatitis, periodontitis and neurodegenerative conditions. Minocycline was shown to have antiviral activity in vitro and also against different viruses in some animal models. Some studies have been done on human patients infected with Human Immunodeficiency Virus. We have review the available data regarding minocycline activity as an antiviral agent.