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Dietary Flavonoids Added to Pharmacological Antihypertensive Therapy are Effective in Improving Blood Pressure
Author(s) -
Jesús RomeroPrado Marina María,
CurielBeltrán Jesús Aarón,
MiramontesEspino María Viviana,
CardonaMuñoz Ernesto Germán,
RiosArellano Angeles,
BalamSalazar LolBe
Publication year - 2015
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/bcpt.12360
Subject(s) - blood pressure , medicine , pharmacology , traditional medicine
Abstract Epidemiological studies have suggested that the daily intake of flavonoids is associated with a decreased risk of developing cardiovascular disease. Our purpose was to evaluate the effect of the addition of dietary flavonoids ( DF ) to antihypertensive treatment ( AHT ), based on telmisartan (Tms) or captopril (Cpr), on blood pressure ( BP ), body mass index ( BMI ), waist/hip ratio, leptin, lipid profile and inflammation in hypertensive young patients. An open‐label, randomized, controlled trial was performed among 79 patients aged 20–55 years with grade I or grade II systemic arterial hypertension. The subjects were assigned to one of four groups for AHT plus DF during 6 months: Cpr (n = 14), Cpr + DF (n = 19), Tms (n = 25) and Tms + DF (n = 21). DF consisted of dark chocolate, dehydrated red apple and green tea in an infusion to obtain a daily dose of 425.8 ± 13.9 mg epicatechin equivalents. The BP and anthropometric parameters were measured every 2 weeks. Lipid profile, leptin and hs CRP were determined by standard methods. The combination AHT ‐ DF produced an additional and significant reduction in (i) SBP / DBP of −5/−4 mmHg, being −7/−5 for Cpr + DF and −4/−3 for Tms + DF ; (ii) triglyceride levels (−30.6%) versus AHT alone (−9.6%); and (iii) leptin: Cpr + DF versus Tms + DF ( p < 0.005). Finally, C‐reactive protein plasma levels were reduced significantly in all groups independently of the applied treatment. We conclude that the addition of flavonoids to pharmacological antihypertensive therapy shows additional benefits on BP , lipid profile, leptin, obesity and inflammation.