Premium
Matrix Metalloproteinases are Involved in Cardiovascular Diseases
Author(s) -
Azevedo Aline,
Prado Alejandro F.,
Antonio Raquel C.,
Issa Joao P.,
Gerlach Raquel F.
Publication year - 2014
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/bcpt.12282
Subject(s) - matrix metalloproteinase , disease , medicine , bioinformatics , intensive care medicine , neuroscience , biology
This MiniReview describes the essential biochemical and molecular aspects of matrix metalloproteinases ( MMP s) and briefly discusses how they engage in different diseases, with particular emphasis on cardiovascular diseases. There is compelling scientific evidence that many MMP s, especially MMP ‐2, play important roles in the development of cardiovascular diseases; inhibition of these enzymes is beneficial to many cardiovascular conditions, sometimes precluding or postponing end‐organ damage and fatal outcomes. Conducting comprehensive discussions and further studies on how MMP s participate in cardiovascular diseases is important, because inhibition of these enzymes may be an alternative or an adjuvant for current cardiovascular disease therapy.