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Evidence for Involvement of Spinal RANTES in the Antinociceptive Effects of Triptolide, a Diterpene Triepoxide, in a Rat Model of Bone Cancer Pain
Author(s) -
Hang LiHua,
Li ShuNa,
Shao DongHua,
Chen Zheng,
Chen YuanFeng,
Shu WeiWei
Publication year - 2014
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/bcpt.12265
Subject(s) - triptolide , nociception , neuropathic pain , medicine , spinal cord , pharmacology , hyperalgesia , bone cancer , analgesic , anesthesia , cancer , chemistry , apoptosis , biochemistry , receptor , psychiatry
It has been shown that triptolide has beneficial effects in the treatment of neuropathic pain, but its effects on bone cancer pain (BCP) remain unclear. In this study, we aimed to explore the potential role of spinal regulated activation of normal T cell expressed and secreted (RANTES) in the antinociceptive effects of triptolide on BCP. A BCP model was induced by injecting Walker 256 mammary gland carcinoma cells into the intramedullary space of rat tibia. Intrathecal administration of triptolide (0.5, 1, 2 μg) could dose‐dependently alleviate mechanical hyperalgesia and spontaneous pain. In addition, there were also concomitant decreases in RANTES m RNA and protein expression levels in spinal dorsal horn. These results suggest that the antinociceptive effects of triptolide are related with inhibition of spinal RANTES expression in BCP rats. The findings of this study may provide a promising drug for the treatment of BCP.