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Adverse Drug Reactions Causing Hospital Admissions in Childhood: A Prospective, Observational, Single‐Centre Study
Author(s) -
Langerová Petra,
Vrtal Jiří,
Urbánek Karel
Publication year - 2014
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/bcpt.12264
Subject(s) - medicine , observational study , pediatrics , prospective cohort study , adverse drug reaction , medical prescription , disease , causality (physics) , drug reaction , antibiotics , drug , adverse effect , emergency medicine , intensive care medicine , pharmacology , physics , quantum mechanics , microbiology and biotechnology , biology
Abstract Adverse drug reactions ( ADR s) are common problems in both paediatric and adult medicine. The aim of this study was to prospectively identify the ADR s causing hospital admission of children and identification of the risk factors and involved drugs. The study was performed at the University Hospital in Olomouc, Czech Republic. All patients aged 19 years or under admitted to hospital were included in the study, and all admissions for ADR s were prospectively screened for a period of 9 months. Suspected ADR s were subsequently evaluated in detail, and causality assessment was undertaken to determine whether each suspected reaction was possible, probable or definite. The assessment of ADR causality was performed using the Naranjo algorithm, the Liverpool ADR Causality Assessment Tool and the Edwards and Aronson causality assessment method. During the study period, 2903 admissions were identified; of these, there were 143 admissions of patients with an oncological disease. Sixty‐four admissions (2.2%) were caused by an ADR . Anticancer chemotherapy accounted for 35% of the cases, followed by antibiotics (18%), immunosuppressants and vaccines (9% each). The use of different scoring systems does not lead to the differences in the numbers of ADR‐diagnosed patient but may result in differences in the determination of the level of certainty. ADR s cause a substantial proportion of children's hospital admissions. The majority of the ADR‐diagnosed patient affected the hematopoietic and gastrointestinal systems; the drugs most frequently involved were cytotoxic agents and antibiotics. The most important risk factors identified were female sex and oncological disease.