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Peripheral Antinociception and Anti‐Inflammatory Effects of Sulphated Polysaccharides from the Alga Caulerpa mexicana
Author(s) -
Carneiro José Gerardo,
Rodrigues José Ariévilo Gurgel,
Sousa Oliveira Vanderlei Edfranck,
Souza Ricardo Basto,
Quinderé Ana Luíza Gomes,
Coura Chistiane Oliveira,
Araújo Ianna Wivianne Fernandes,
Chaves Hellíada Vasconcelos,
Bezerra Mirna Marques,
Benevides Norma Maria Barros
Publication year - 2014
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/bcpt.12234
Subject(s) - polysaccharide , peripheral , chemistry , medicine , biochemistry
Abstract Sulphated polysaccharides from marine algae are widely used in biotechnological and pharmaceutical areas. In this study, we evaluated the effects of sulphated polysaccharides from the green marine alga Caulerpa mexicana (Cm‐ SP s) in nociceptive and inflammatory models in rodents. Cm‐ SP s (10 or 20 mg/kg), administered i.v. in Swiss mice, significantly reduced nociceptive responses, as measured by the number of writhes in response to acetic acid. Cm‐ SP s (10 or 20 mg/kg) also reduced second‐phase responses in the formalin test, but did not exhibit a significant antinociceptive effect in the hot plate test, suggesting that its antinociceptive action occurs through a peripheral mechanism. Cm‐ SP s (5, 10 or 20 mg/kg), administered s.c. in wistar rats 1 hr before carrageenan, dextran, histamine or serotonin, were tested in paw oedema models. Cm‐ SP s (10 or 20 mg/kg) reduced carrageenan‐induced paw oedema and myeloperoxidase activity in the paw. In addition, Cm‐ SP s (20 mg/kg) inhibited dextran‐ or histamine‐induced paw oedema, but not serotonin‐induced oedema, suggesting that histamine is the major target of Cm‐ SP s anti‐oedematogenic activity. Finally, Cm‐ SP s (20 mg/kg) administered in mice did not show significant signs of toxicity. In conclusion, Cm‐ SP s appear to be promising natural modulatory agents for pain and inflammatory conditions.