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Exposure to Bisphenol A Affects Lipid Metabolism in Drosophila melanogaster
Author(s) -
Williams Michael J.,
Wang Yi,
Klockars Anica,
Monica Lind P.,
Fredriksson Robert,
Schiöth Helgi B.
Publication year - 2014
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/bcpt.12170
Subject(s) - drosophila melanogaster , starvation , lipolysis , lipid metabolism , endocrinology , medicine , drosophila (subgenus) , biology , metabolism , chemistry , biochemistry , adipose tissue , gene
Exposure to bisphenol A ( BPA ) in rodents was shown to induce obesity, yet the mechanism by which BPA might induce obesity is still unclear. We employed the genetically tractable model organism, D rosophila melanogaster , to test the effects of raising them on food containing various concentrations of BPA . Of note, raising males on food containing BPA were susceptible to starvation, possibly by inhibiting their ability to perform lipolysis during starvation, leading to significantly increased lipid content after 24 hr of fasting. Furthermore, feeding males with BPA significantly inhibited the expression of insulin‐like peptides. From these results, we conclude that BPA may inhibit lipid recruitment during starvation in D rosophila .