Premium
The Neuro‐Immune Axis: Prospect for Novel Treatments for Mental Disorders
Author(s) -
Kraneveld Aletta D.,
Theije Caroline G.M.,
Heesch Floor,
Borre Yuliya,
Kivit Sander,
Olivier Berend,
Korte Mechiel,
Garssen Johan
Publication year - 2014
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/bcpt.12154
Subject(s) - immune system , autism , neuroscience , central nervous system , major depressive disorder , depression (economics) , autism spectrum disorder , medicine , psychology , cognition , psychiatry , immunology , economics , macroeconomics
Disturbed bidirectional pathways between the (central) nervous system and immune system have been implicated in various mental disorders, including depressive and neurodevelopmental disorders. In this minireview, the role of the neuro‐immune axis and its targetability in relation to major depression and autism spectrum disorder will be discussed. All together, the management of these and possibly other multi‐factorial mental disorders needs a new and integrated therapeutic approach. Pharmacologically bioactive molecules as well as medical nutrition targeting the (gut)–immune–brain axis could be such an approach.