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Inhibitors of the Arachidonic Acid Cascade: Interfering with Multiple Pathways
Author(s) -
Meirer Karin,
Steinhilber Dieter,
Proschak Ewgenij
Publication year - 2014
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/bcpt.12134
Subject(s) - arachidonic acid , epoxide hydrolase 2 , cytochrome p450 , cyclooxygenase , inflammation , pharmacology , chemistry , computational biology , biology , biochemistry , enzyme , immunology
Modulators of the arachidonic acid cascade have been in the focus of research for treatments of inflammation and pain for several decades. Targeting this complex pathway experiences a paradigm change towards the design and development of multi‐target inhibitors, exhibiting improved efficacy and less undesired side effects. This minireview summarizes recent developments in the field of designed multi‐target ligands of the arachidonic acid cascade. In addition to the well‐known dual inhibitors of 5‐lipoxygenase and cyclooxygenase‐2 such as licofelone, very recent developments are discussed. Especially, multi‐target inhibitors interfering with the cytochrome P450 pathway via inhibition of soluble epoxide hydrolase seem to offer a novel opportunity for development of novel anti‐inflammatory drugs.