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Micro RNA s – Novel Therapeutic Targets of Eicosanoid Signalling
Author(s) -
Ochs Meike J.,
Steinhilber Dieter,
Suess Beatrix
Publication year - 2014
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/bcpt.12116
Subject(s) - eicosanoid , microrna , signalling pathways , signalling , prostanoid , eicosanoid metabolism , hedgehog signaling pathway , biology , microbiology and biotechnology , enzyme , signal transduction , computational biology , genetics , biochemistry , receptor , gene , arachidonic acid
Micro RNA s (mi RNA s) have emerged as important regulators in human physiological and pathological processes. We summarize the current knowledge about the role of mi RNA involved in the control of inflammatory responses with a special focus on eicosanoid signalling. Cyclooxygenase 2 – the key enzyme of the prostanoid pathway – is regulated by different mi RNA s such as mi RNA ‐101, miR199a, miR26b and miR‐146a. In contrast to this, the understanding of mi RNA regulation on enzymes of the leukotriene biosynthesis is just at the beginning. The knowledge of mi RNA s regulating enzymes of the eicosanoid pathway offers a new way for the development of new therapeutic concepts for the treatment of inflammatory diseases.