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5‐Lipoxygenase m RNA and Protein Isoforms
Author(s) -
Ochs Meike J.,
Suess Beatrix,
Steinhilber Dieter
Publication year - 2014
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/bcpt.12115
Subject(s) - gene isoform , arachidonate 5 lipoxygenase , lipoxygenase , arachidonic acid , lipid signaling , splice , alternative splicing , inflammation , leukotriene , rna , biochemistry , chemistry , biology , asthma , enzyme , immunology , gene
5‐Lipoxygenase (5‐ LO ) catalyses the two initial steps in the biosynthesis of leukotrienes, a group of inflammatory lipid mediators derived from arachidonic acid. An increased level of leukotrienes is associated with chronic inflammatory diseases such as asthma or atherosclerosis. In this M ini R eview, we focus on recent findings regarding alternative splice variants of 5‐ LO with a special emphasis on two potential protein isoforms expressed in human B ‐lymphocytes which might be of interest as new drug targets.