5‐Lipoxygenase m RNA  and Protein Isoforms | Zendy

Ochs Meike J. | Zendy; Suess Beatrix | Zendy; Steinhilber Dieter | Zendy

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5‐Lipoxygenase m RNA and Protein Isoforms

Author(s) -

Ochs Meike J.,

Suess Beatrix,

Steinhilber Dieter

Publication year - 2014

Publication title -

basic and clinical pharmacology and toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.805

H-Index - 90

eISSN - 1742-7843

pISSN - 1742-7835

DOI - 10.1111/bcpt.12115

Subject(s) - gene isoform , arachidonate 5 lipoxygenase , lipoxygenase , arachidonic acid , lipid signaling , splice , alternative splicing , inflammation , leukotriene , rna , biochemistry , chemistry , biology , asthma , enzyme , immunology , gene

5‐Lipoxygenase (5‐ LO ) catalyses the two initial steps in the biosynthesis of leukotrienes, a group of inflammatory lipid mediators derived from arachidonic acid. An increased level of leukotrienes is associated with chronic inflammatory diseases such as asthma or atherosclerosis. In this M ini R eview, we focus on recent findings regarding alternative splice variants of 5‐ LO with a special emphasis on two potential protein isoforms expressed in human B ‐lymphocytes which might be of interest as new drug targets.

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