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Purinoceptor‐mediated, Capsaicin‐resistant Excitatory Effect of Allyl Isothiocyanate on Neurons of the Guinea‐Pig Small Intestine
Author(s) -
Bartho Lorand,
Nordtveit Elin,
Szombati Veronika,
Benko Rita
Publication year - 2013
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/bcpt.12060
Subject(s) - capsaicin , hexamethonium , tetrodotoxin , atropine , chemistry , ppads , allyl isothiocyanate , small intestine , guinea pig , pharmacology , cholinergic , purinergic receptor , endocrinology , medicine , biology , biochemistry , receptor
Allyl isothiocyanate ( AITC ; 200 μM) caused atropine‐ and tetrodotoxin‐sensitive longitudinal muscle contraction on the guinea‐pig small intestine. The response was not influenced by hexamethonium, a functional blockade of capsaicin‐sensitive neurons or by antagonists acting at TRPV 1 or TRPA 1, but was abolished by the P 2 purinoceptor antagonist PPADS (50 μM). It is concluded that cholinergic motoneurons are activated by a purinergic mechanism in the course of the AITC response, independently of capsaicin‐sensitive processes or even TRPA 1.