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Retracted: Quercetin Decreases Liver Damage in Mice with Non‐Alcoholic Steatohepatitis
Author(s) -
Marcolin Éder,
Forgiarini Luiz Felipe,
Rodrigues Graziella,
Tieppo Juliana,
Borghetti Greice Stefani,
Bassani Valquiria Linck,
Picada Jaqueline Nascimento,
Marroni Norma Possa
Publication year - 2013
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/bcpt.12049
Subject(s) - steatohepatitis , steatosis , liver damage , fatty liver , medicine , oxidative stress , lipid peroxidation , liver injury , alcoholic liver disease , dna damage , quercetin , methionine , chemistry , endocrinology , antioxidant , biochemistry , cirrhosis , disease , dna , amino acid
Abstract Non‐alcoholic steatohepatitis ( NASH ) is a frequent condition in obese patients that may progress to end‐stage liver disease. This study was designed to evaluate the modulation of this condition by use of quercetin (Q), a flavonoid largely found in vegetable foods, with known anti‐inflammatory and antioxidant properties, in the experimental model of non‐alcoholic steatohepatitis ( NASH ) using a diet deficient in methionine and choline ( MCD ). Male C57 BL 6 mice were divided into four groups (n = 16): (i) Control plus vehicle (control ration plus carboxymethylcellulose 1% used as vehicle, CO + V); (ii) Control ration plus Q 50 mg/kg ( CO + Q); (iii) MCD diet plus vehicle ( NASH + V); and (iv) MCD diet plus Q ( NASH + Q). Diets were administered for 4 weeks. At the end of the experimental period, liver alterations, bioindicators of oxidative stress and DNA damage were assessed. NASH was diagnosed in 100% of the mice that were fed the MCD diet. In addition, a significant increase in DNA damage in liver tissue from NASH + V group was observed in comparison with CO + V. The group NASH + Q showed a significant decrease in hepatic damage enzymes, lipoperoxidation, DNA damage and a lower degree of macrovesicular steatosis, ballooning and inflammatory process. These findings suggest that Q may have protective effects by improving liver integrity in NASH .