Retracted: Quercetin Decreases Liver Damage in Mice with Non‐Alcoholic Steatohepatitis

Non‐alcoholic steatohepatitis ( NASH ) is a frequent condition in obese patients that may progress to end‐stage liver disease. This study was designed to evaluate the modulation of this condition by use of quercetin (Q), a flavonoid largely found in vegetable foods, with known anti‐inflammatory and antioxidant properties, in the experimental model of non‐alcoholic steatohepatitis ( NASH ) using a diet deficient in methionine and choline ( MCD ). Male C57 BL 6 mice were divided into four groups (n = 16): (i) Control plus vehicle (control ration plus carboxymethylcellulose 1% used as vehicle, CO  + V); (ii) Control ration plus Q 50 mg/kg ( CO  + Q); (iii) MCD diet plus vehicle ( NASH  + V); and (iv) MCD diet plus Q ( NASH  + Q). Diets were administered for 4 weeks. At the end of the experimental period, liver alterations, bioindicators of oxidative stress and DNA damage were assessed. NASH was diagnosed in 100% of the mice that were fed the MCD diet. In addition, a significant increase in DNA damage in liver tissue from NASH  + V group was observed in comparison with CO  + V. The group NASH  + Q showed a significant decrease in hepatic damage enzymes, lipoperoxidation, DNA damage and a lower degree of macrovesicular steatosis, ballooning and inflammatory process. These findings suggest that Q may have protective effects by improving liver integrity in NASH .