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Effects of Ethanolic Extract and Naphthoquinones Obtained from the Bulbs of C ipura paludosa on Short‐Term and Long‐Term Memory: Involvement of Adenosine A 1 and A 2A Receptors
Author(s) -
Lucena Greice M. R. S.,
Matheus Filipe C.,
Ferreira Vania M.,
Tessele Priscila B.,
Azevedo Mariangela S.,
CechinelFilho Valdir,
Prediger Rui D.
Publication year - 2013
Publication title -
basic and clinical pharmacology and toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.805
H-Index - 90
eISSN - 1742-7843
pISSN - 1742-7835
DOI - 10.1111/bcpt.12022
Subject(s) - caffeine , pharmacology , adenosine receptor , antagonist , adenosine receptor antagonist , adenosine , chemistry , inhibitory postsynaptic potential , receptor , medicine , biochemistry , agonist
Previous studies from our group have indicated important biological properties of the ethanolic extract and isolated compounds from the bulbs of C ipura paludosa ( I ridaceae), a native plant widely distributed in northern Brazil, including antioxidant, neuroprotective and anti‐nociceptive activities. In the present study, the effects of the ethanolic extract and its two naphthoquinones (eleutherine and isoeleutherine) on the short‐ and long‐term memory of adult rodents were assessed in social recognition and inhibitory avoidance tasks. Acute pre‐training oral administration of the ethanolic extract improved the short‐term social memory in rats as well as facilitated the step‐down inhibitory avoidance short‐ and long‐term memory in mice. Moreover, the co‐administration of ‘non‐effective’ doses of the extract of C ipura paludosa and the adenosine receptor antagonists caffeine (non‐selective), DPCPX (adenosine A 1 receptor antagonist) and ZM 241385 (adenosine A 2A receptor antagonist) improved the social recognition memory of rats. In the inhibitory avoidance task, the co‐administration of sub‐effective doses of the extract with caffeine or ZM 241385, but not with DPCPX , improved the short‐ and long‐term memory of mice. Finally, the acute oral administration of eleutherine and isoeleutherine facilitated the inhibitory avoidance short‐ and long‐term memory in mice. These results demonstrate for the first time the cognitive‐enhancing properties of the extract and isolated compounds from the bulbs of C ipura paludosa in rodents and suggest a possible involvement of adenosine A 1 and A 2A receptors in these effects.