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Pharmacokinetically guided dosing has the potential to improve real‐world outcomes of pazopanib
Author(s) -
Fukudo Masahide,
Tamaki Gaku,
Azumi Makoto,
Shibata Hiroaki,
Tandai Susumu
Publication year - 2021
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/bcp.14580
Subject(s) - dosing , medicine , discontinuation , pazopanib , adverse effect , confidence interval , therapeutic drug monitoring , randomized controlled trial , pharmacokinetics , sunitinib , renal cell carcinoma
It remains unclear whether therapeutic drug monitoring (TDM) of pazopanib improves treatment outcomes in routine clinical practice. We did a prospective cohort study to evaluate the benefits of TDM for pazopanib therapy in real‐world practice. Among 25 patients with pharmacokinetically guided dosing, only 5 (20%, 95% confidence interval 6.8–40.7%) discontinued treatment because of adverse events. However, 5 (41.7%, 95% confidence interval 15.2–72.3%) of historical controls including 12 patients not receiving such a strategy experienced adverse events leading to early termination. PK‐guided dosing significantly increased median time‐to‐treatment discontinuation (252 vs 74 days, P = .012) with reduced toxicity and improved overall survival (not reached vs 313 days, P = .002) relative to conventional dosing in the control group. In conclusion, PK‐guided dose adaptation through the use of TDM has the potential to improve treatment outcomes of pazopanib in routine clinical practice, warranting larger, randomized studies.