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A meta‐analysis of the influence of ADRB2 genetic polymorphisms on albuterol (salbutamol) therapy in patients with asthma
Author(s) -
Hikino Keiko,
Kobayashi Shinobu,
Ota Erika,
Mushiroda Taisei,
Urayama Kevin Y.,
Kobayashi Tohru
Publication year - 2021
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/bcp.14570
Subject(s) - medicine , asthma , confidence interval , meta analysis , salbutamol , relative risk
Aims The associations of 2 nonsynonymous single nucleotide polymorphisms (Arg16Gly and Gln27Glu) in the adrenoceptor β2 ( ADRB2 ) gene with response after albuterol use are conflicting. We conducted a meta‐analysis to examine the cumulative evidence of the effects of these 2 variants on percent forced expiratory volume in 1 second (FEV1.0%) after albuterol use in asthma patients. Methods We conducted a comprehensive literature search using MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials to identify studies examining the association between ADRB2 Arg16Gly and Gln27Glu and FEV1.0% shortly after albuterol administration. The individual study results were combined with weights based on the inverse variance method. This systematic review was registered in the PROSPERO (registration number: CRD42019074554). Results Among 273 initial studies identified, 7 studies met the inclusion criteria for quantitative evaluation. Results of the overall meta‐analysis indicated no statistically significant mean difference of FEV1.0% between genotypes of Arg16Gly and Gln27Glu. In subgroup analyses, significant associations were found for Arg16Gly GG ( vs AA) among studies where no methacholine bronchoconstriction was conducted (mean difference, −3.92; 95% confidence interval, −7.29 to −0.54; I 2 = 0%), and for Arg16Gly GG ( vs GA) among studies that included patients with no comorbidities (mean difference, −1.93; 95% confidence interval, −3.77 to −0.10; I 2 = 0%). Conclusion Synthesis of the studies to date shows weak evidence for an association between ADRB2 Arg16Gly and Gln27Glu and FEV1.0% after albuterol use, results of which underscore significant heterogeneity across studies and the need for careful design and sample size considerations.