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Population pharmacokinetics and Bayesian estimators for intravenous mycophenolate mofetil in haematopoietic stem cell transplant patients
Author(s) -
Labriffe Marc,
Vaidie Julien,
Monchaud Caroline,
Debord Jean,
Turlure Pascal,
Girault Stephane,
Marquet Pierre,
Woillard JeanBaptiste
Publication year - 2020
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/bcp.14261
Subject(s) - mycophenolic acid , mycophenolate , pharmacokinetics , nonmem , population , transplantation , medicine , pharmacology , environmental health
Intravenous mycophenolate mofetil (IV MMF), a prodrug of mycophenolic acid (MPA), is used during nonmyeloablative and reduced-intensity conditioning haematopoetic stem cell transplantation (HCT) to improve engraftment and reduce graft-versus-host disease. The aims of this study were to develop population pharmacokinetic models and Bayesian estimators based on limited sampling strategies to allow for individual dose adjustment of intravenous mycophenolate mofetil administered by infusion in haematopoietic stem cell transplant patients.