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Hesperidin supplementation has no effect on blood glucose control: A systematic review and meta‐analysis of randomized controlled clinical trials
Author(s) -
ShamsRad Shamim,
Mohammadi Mohammad,
RamezaniJolfaie Nahid,
Zarei Sadegh,
Mohsenpour Mohammadali,
SalehiAbargouei Amin
Publication year - 2020
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/bcp.14120
Subject(s) - hesperidin , medicine , meta analysis , randomized controlled trial , insulin resistance , confidence interval , publication bias , insulin , alternative medicine , pathology
Aims To the best of our knowledge, no study has tried to quantitatively summarize the published evidence regarding the effect of hesperidin supplementation on blood glucose control. The present systematic review and meta‐analysis of randomized controlled trials aimed to determine the effectiveness of hesperidin supplementation in improving blood glucose control in adults. Methods Electronic databases including PubMed, ISI Web of Science, Scopus, and Google Scholar were searched up to February 2019. The risk of bias in individual studies was assessed using the Cochrane collaboration's tool. The overall estimates and their 95% confidence intervals (CIs) were calculated using a random‐effects model. Results Six trials with 318 participants were reviewed in the present systematic review. The results showed that hesperidin had no significant effect on serum fasting blood glucose (weighted mean difference [WMD] = −1.10 mg/dL, 95% CI: −3.79, 1.57), plasma insulin (WMD = −0.01 μU/mL, 95% CI: −1.20, 1.19), glycated haemoglobin A1c (WMD = −0.04%, 95% CI: −0.14, 0.04), homeostasis model assessment for insulin resistance (WMD = 0.117, 95% CI: −0.06, 0.29) and quantitative insulin sensitivity check index (WMD = 0.135; 95% CI: −0.13, 0.39), with no significant between‐study heterogeneity. Subgroup analyses also indicated that the effects were not different based on the studies' design and duration, or the health status of the participants. Conclusion Although several animal studies have proposed that hesperidin supplementation might improve blood glucose control, the present study could not confirm this benefit in humans.