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Therapeutic drug monitoring of infliximab in spondyloarthritis. A review of the literature
Author(s) -
Fobelo Lozano María José,
Serrano Giménez Reyes,
Sánchez Fidalgo Susana
Publication year - 2019
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/bcp.14062
Subject(s) - medicine , infliximab , psoriatic arthritis , ankylosing spondylitis , ulcerative colitis , inflammatory bowel disease , rheumatoid arthritis , psoriasis , adalimumab , drug , therapeutic drug monitoring , tumor necrosis factor alpha , golimumab , etanercept , crohn's disease , arthritis , disease , gastroenterology , immunology , pharmacokinetics , pharmacology
Available evidence indicates that a therapeutic drug monitoring strategy leads to major cost savings related to the anti‐tumour necrosis factor‐α therapy in both inflammatory bowel disease and rheumatoid arthritis (RA) patients, with no negative impact on efficacy. However, although the systematic use of therapeutic drug monitoring could potentially be beneficial and economically acceptable to drug dose optimization, it is not justifiable for all drugs. Infliximab (IFX) is a chimeric monoclonal immunoglobulin G1 targeting tumour necrosis factor. It has been approved for the treatment of immuno‐inflammatory diseases, including RA, ankylosing spondylitis, psoriatic arthritis, Crohn's disease and ulcerative colitis. IFX's pharmacokinetics is highly variable and influences clinical response in chronic inflammatory diseases. Clinical response increases with IFX trough concentrations in RA, ankylosing spondylitis, inflammatory bowel disease and psoriatic patients. Target concentrations predictive of good clinical response were proposed in RA, Crohn's disease and ulcerative colitis. The purpose of this article is to review the current literature surrounding IFX serum concentrations and their related parameters with disease activity in patients with spondyloarthritis. Gathering information about the efficacy of IFX in patients with spondyloarthritis and relating IFX serum concentrations to disease activity were the main goals of this study.