z-logo
Premium
The rationale of dose–response curves in selecting cancer drug dosing
Author(s) -
Martin Jennifer H.,
Dimmitt Simon
Publication year - 2019
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/bcp.13979
Subject(s) - dosing , medicine , drug , pharmacology , cancer , pharmacokinetics , drug response , oncology
Drug development for cancer chemotherapy has an interesting history. A mix of serendipity, animal, cell line, and standard pharmacological principles of dose, dose‐response, dose‐concentration, dose intensity and combination therapies have been used to develop optimal dosing schedules. However in practice, significant gaps in the translation of preclinical to clinical dosing schedules persist, and clinical development has instead moved to new drug development. A older chemotherapies are still the backbone of most solid tumour schedules, therapeutic drug monitoring has emerged as a method for optimising the dose for individual patients.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here