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CYP2E1 activity and children with obesity: possible confounding factors
Author(s) -
Kaur Hardeep,
Sarma Phulen,
Prakash Ajay,
Medhi Bikash
Publication year - 2019
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/bcp.13769
Subject(s) - confounding , cyp2e1 , medicine , obesity , environmental health , biology , cytochrome p450 , metabolism
Lots of factors can influence CYP2E1 activities, e.g. thyroid status, different types of anaemia (fanconi anaemia and sideroblastic anaemia), etc. Alcohol is a known inducer of CYP2E1, therefore a justifiable duration of abstinence is required before the subjects are enrolled into a study for normalization of CYP2E1 activity. In this letter we address these confounding factors and their role in CYP2E1 activity.