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Use of antipsychotics and risk of myocardial infarction: a systematic review and meta‐analysis
Author(s) -
Yu Zhenghe,
Jiang Haiyin,
Shao Li,
Zhou Yuanyue,
Shi Haiyan,
Ruan Bing
Publication year - 2016
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/bcp.12985
Subject(s) - observational study , medicine , antipsychotic , odds ratio , meta analysis , confidence interval , subgroup analysis , myocardial infarction , schizophrenia (object oriented programming) , psychiatry
Aim There is emerging concern that antipsychotics may be associated with an increased risk of myocardial infarction (MI). A previous review identified five observational studies that did not provide an accurate estimate of the association between antipsychotic drug use and MI risk. More recent studies have produced variable results. Methods We performed a systematic review and meta‐analysis of observational studies to determine whether antipsychotic use affects the risk for MI. Our analysis included all observational studies that compared MI incidence among patients receiving antipsychotics vs . no treatment. Results Nine observational studies were included in the analysis. The odds for developing MI were 1.88‐fold higher (odds ratio (OR) 1.88, 95% confidence interval (CI) 1.39, 2.54) in antipsychotic users compared with individuals who had not taken antipsychotics. Subgroup analyses found an OR of 2.48 (95% CI 1.66, 3.69) among patients with schizophrenia and an OR of 2.64 (95% CI 2.48, 2.81) among short term (<30 days) antipsychotic users. Conclusion The findings of this meta‐analysis support an increased risk of MI in antipsychotic drug users. The present systematic review expands previous knowledge by demonstrating an increased and more pronounced risk in short term users.